11.04.2022
Fourier-transform infrared spectroscopy (FT-IR) in combination with machine learning and chemometrics is an intensively developed, powerful tool for investigation of tissue biochemical composition with simultaneous microscopic visualization. This nondestructive, information rich and label-free technique has been successfully applied in cancer diagnostics. During the development of a disease or inflammatory processes, not only the chemical composition of tissues changes, but also their spatial organization. FT-IR imaging with linear polarization can provide new and useful information about chemically-specific orientation of macromolecules. The team of SOLAIR beamline presented their results of spatial macromolecular orientation in human, pancreatic tissue using four-polarization FT-IR method.
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