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Research
Retrovirus research using Cryo-EM
11.04.2022
Reverse transcription involves the conversion of single-stranded RNA to double-stranded DNA. This is a key step in the replication of retroviruses, catalyzed by the enzyme reverse transcriptase. Retroviruses are divided into two subfamilies, one of which, Spumaretrovirinae, has a different proliferation cycle and a different reverse transcriptase domain structure. The presented studies provide the first structural description of the nucleic acid binding by viral reverse transferase, demonstrating its ability to change the oligomeric state depending on the type of bound nucleic acid.
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Titanium dioxide is the hero of the first IFJ PAN research in Solaris!
11.04.2022
Not so many compounds are as important to industry and medicine today as titanium dioxide (TiO2). The electronic structure of transition metal oxides is an important factor determining the chemical and optical properties of materials. Specifically for metal-oxide structures, the crystal-field interaction determines the shape and occupancy of electronic orbitals. Consequently, the crystal-field splitting and resulting unoccupied state populations can be foreseen as modeling factors of the photochemical activity. The research on titanium dioxide inaugurated the presence of IFJ PAN scientists in research programs carried out at the SOLARIS synchrotron. The measurements, co-financed by the National Science Center, were carried out at the XAS beamline.
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Adaptation of infrared imaging to the economic requirements of the clinic
11.04.2022
The FT-IR spectroscopic imaging in combination with machine learning algorithms has a great potential as a support for histopathologists in distinguishing types of tissues and cancer diagnosis. The introduction of the method to clinical practice is limited by the relatively high cost of sample substrates and the long preparation and measurement time. Depending on the selected measurement mode (radiation transmission or transflection), two types of sample carriers are particularly applicable.
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A new chapter in QPI imaging of the biological material
08.09.2020
A group of researchers, including SOLARIS scientist Dr. Tomasz Wróbel, contributed to the improvement of imaging methods by creating a new technique: confocal QPI - Quantitative Phase Imaging.
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Macromolecular Orientation – the New Frontier in Cancer Research
11.04.2022
The prestigious journal ‘Analytical Chemistry’ (IF: 6.785) has recently published a paper written by the SOLARIS team and titled ”Macromolecular orientation in biological tissues using a four-polarization method in FT-IR imaging”.
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